Endocrine Abstracts

Background: Language development during early childhood is considered an important marker of fetal neurodevelopment. Prenatal cortisol exposure plays a critical role in maturation of the fetal brain; however, the effect on offspring language development needs further investigation. This study aimed to evaluate the association between maternal 3rd trimester cortisol and early longitudinal offspring language development and to test whether there was sex differences in...

Background: Higher testosterone levels during pregnancy in women with polycystic ovary syndrome (PCOS) could be associated with longer offspring ano-genital distance (AGD).Aims: To compare AGD between offspring of mothers with PCOS and controls and to determine possible associations between maternal 3rd trimester testosterone levels and offspring AGD at three months of age.Methods: The study was part of the prospective s...

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals, with elimination half-lives ranging from four to eight years. Experimental studies found PFAS able to interfere with thyroid hormone-binding proteins. During the first 20 weeks of gestation (GW), the fetus is reliant on placental transfer of maternal thyroid hormones, mainly free thyroxine (FT4). However, previous studies investigating associations between exposure to PFAS and thyroid hormone stat...

Background: Prolactin is associated with metabolic risk inside and outside of pregnancy. Maternal prolactin levels could be associated with offspring body composition.Aim: To investigate if maternal prolactin-levels were linked to offspring body composition at seven years of age.Design: Prospective observational cohort study (the Odense Child Cohort).Methods: Maternal fasting blood samples were assessed durin...